Furthermore, various nanoparticles have been used for delivering drug molecules to tumors, (1-3) and several nanotherapeutics have entered into clinical trials worldwide.
Food and Drug Administration (FDA) on the basis of their improved efficacy or reduced toxicity over the parent drugs, for example, stealth liposomal formulations of doxorubicin (Doxil) and the human serum albumin bounded paclitaxel nanoparticle (Abraxane). Several nanomedicines have been approved by the U.S.
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The in vivo and ex vivo small animal imaging revealed the preferred tumor accumulation and the prolonged tumor residency of the payload delivered by the cross-linked micelles compared to the non-cross-linked micelles and free drug surrogate because of the increased stability. The engineered nanocarrier possesses good drug loading capacity and stability, and exhibits a safer profile as well as similar anticancer effects compared with free drug in cell culture. Coumarin and disulfide bond was introduced into a linear-dendritic copolymer (named as telodendrimer) precisely via peptide chemistry. At the same time, cross-linking of nanocarrier could be cleaved via the responsiveness of the built-in disulfide cross-linkage to the redox tumor microenvironment for on-demand drug release. The nanocarrier can be cross-linked efficiently via a clean, efficient, and controllable coumarin photodimerization within the nanocarrier, which simplify the formulation process and quality control prior clinical use and improve the in vivo stability for tumor targeting.
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Google Patents Process for photochemical activation of polymer surface and immobilization of biomolecules onto the activated surfaceÄownload PDF Info Publication number US7629016B2 US7629016B2 US10/166,292 US16629202A US7629016B2 US 7629016 B2 US7629016 B2 US 7629016B2 US 16629202 A US16629202 A US 16629202A US 7629016 B2 US7629016 B2 US 7629016B2 Authority US United States Prior art keywords polymer activated biomolecule fluoro immobilization Prior art date Legal status (The legal status is an assumption and is not a legal conclusion. Google Patents US7629016B2 - Process for photochemical activation of polymer surface and immobilization of biomolecules onto the activated surface US7629016B2 - Process for photochemical activation of polymer surface and immobilization of biomolecules onto the activated surface